On Fedora, if you have mate-desktop or cinnamon-desktop installed, your GNOME touchpad configuration panel won't work (see Bug 1338585). Both packages install a symlink to assign the synaptics driver to the touchpad. But GNOME's control-center does not support synaptics anymore, so no touchpad is detected. Note that the issue occurs regardless of whether you use MATE/Cinnamon, merely installing it is enough.
Unfortunately, there is no good solution to this issue. Long-term both MATE and Cinnamon should support libinput but someone needs to step up and implement it. We don't support run-time driver selection in the X server, so an xorg.conf.d snippet is the only way to assign a touchpad driver. And this means that you have to decide whether GNOME's or MATE/Cinnamon's panel is broken at X start-up time.
If you need the packages installed but you're not actually using Mate/Cinnamon itself, remove the following symlinks (whichever is present on your system):
# rm /etc/X11/xorg.conf.d/99-synaptics-mate.conf # rm /etc/X11/xorg.conf.d/99-synaptics-cinnamon.conf # rm /usr/share/X11/xorg.conf.d/99-synaptics-mate.conf # rm /usr/share/X11/xorg.conf.d/99-synaptics-cinnamon.confThe /usr/share paths are the old ones and have been replaced with the /etc/ symlinks in cinnamon-desktop-3.0.2-2.fc25 and mate-desktop-1.15.1-4.fc25 and their F24 equivalents.